The present study was aimed to develop in-situ gel of carvedilol for improved bioavailability by circumventing the hepatic first pass metabolism and patient compliance. The carvedilol in-situ gelling system was formulated by using carbopol 934 in combination with HPMC K4M by cold technique to reduce the mucociliary clearance and thereby it will increase the contact of formulation with nasal mucosa and hence improving drug absorption. The prepared gels were characterized by viscosity, pH, drug content, gel strength, in-vitro diffusion study, permeation studies, stability study etc. In this formulation the release profile depend on the concentration of carbopol 934 and HPMC K4M. A 32 factorial was applied to see the effect of varying the concentration variables carbopol 934 (X1) and HPMC K4M (X2). In-vitro release data were fitted to various models to ascertain kinetic of drug release. Regression analysis and analysis of variance were performed for dependent variables. Formulation containing carbopol 934p (0.3%) and HPMC K4M (0.1%) was found to be optimum. The optimized formulation showed a drug release of 98.75% in 480 min. The biopolymers used and their compositions in the in-situ gels preparation greatly affected the drug release which allows absorption in the nasal mucosa.
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